Mitoxantrone CAS: 65271-80-9 98% purity
Product Description
Mitoxantrone (Novantrone) is a synthetic anthraquinone that is structurally and mechanistically related to the anthracyclines. It intercalates with DNA and produces single- strand DNA breakage. It is cross-resistant with doxorubicin in multidrug-resistant cells and in patients who have failed to respond to doxorubicin therapy.
Mitoxantrone is active against breast carcinomas, leukemias, and lymphomas. Its antitumor efficacy in patients with breast cancer is slightly lower than that of doxorubicin. Its major toxicity is myelosuppression; mucositis and diarrhea also may occur. Mitoxantrone produces less nausea, alopecia, and cardiac toxicity than does doxorubicin.
Product Properties
Product Name: Mitoxantrone APIs
Appearance: A dark-blue powder
Solubility: Slightly soluble or almost insoluble in water
Cas Number: 65271-80-9
Molecular Formula: C22H28N4O6
Molecular Weight: 444.5 g/mol
Chemical Name: 1,4-dihydroxy-5,8-bis[2-(2-hydroxyethylamino)ethylamino]anthracene-9,10-dione
Suitability to be shipped by courier as common goods: suitable. It is safe to be shipped by air as common goods.
Purity or Assay: 99%
Standards: Current Enterprise/USP Standards
Certificates available: ISO
Documents Available: COA/MSDS
Supply Capability: 1KG per month
MOQ: 1 Gram
Application
Mitoxantrone is a DNA intercalating drug. Mitoxantrone inhibits DNA synthesis. Mitoxantrone is used as an anti-cancer agent.
Mitoxantrone may be useful in the treatment of several neoplastic diseases in dogs and cats, including lymphosarcoma mammary adenocarcinoma, squamous cell carcinoma, renal adenocarcinoma, fibroid sarcoma, thyroid or transitional cell carcinomas, and hemangiopericytoma.
Because renal clearance of the drug is minimal (10%), it may be administered to cats with renal insufficiency much more safely than doxorubicin.
Doctors use it to treat prostate cancer and certain types of leukemia.
It works as a Topoisomerase Inhibitor.
Packing & Storage
Packing: 1g/5g/10g/100g per package
Storage: Keep in dark place,Sealed in dry,2-8°C
Specification
| Name | Mitoxantrone | ||
| CAS | 65271-80-9 | ||
| Items | Standard | Results | |
| Appearance | Dark-blue powder | Conforms | |
| Assay, % | ≥99 | 99.1 | |
| Conclusion | Qualified | ||
