Ama-alkyne atholakala kabanzi emikhiqizweni yemvelo, kuma-molecule asebenzayo ngokwezinto eziphilayo kanye nezinto ezisebenzayo zezinto eziphilayo. Ngesikhathi esifanayo, nawo angama-intermediate abalulekile ekuhlanganisweni kwezinto eziphilayo futhi angabhekana nokusabela okuningi kokuguqulwa kwamakhemikhali. Ngakho-ke, ukuthuthukiswa kwezindlela zokwakha ama-alkyne ezilula nezisebenzayo kuyadingeka kakhulu. Nakuba ukusabela kwe-Sonogashira okubangelwa yizinsimbi zokuguquguquka kungenye yezindlela eziphumelela kakhulu futhi ezilula zokuhlanganisa ama-alkyne ashintshiwe yi-aryl noma i-alkenyl, ukusabela kokuhlanganisa okubandakanya ama-alkyl electrophiles angasebenzi kungenxa yokusabela okungekuhle njengokususwa kwe-bH. Kusagcwele izinselele kanye nocwaningo oluncane, ikakhulukazi olukhawulelwe kuma-alkanes angenabungani nemvelo futhi abizayo e-halogenated. Ngakho-ke, ukuhlola kanye nokuthuthukiswa kokusabela kwe-Sonogashira kwama-reagents amasha, angabizi futhi atholakala kalula e-alkylation kuzoba nokubaluleka okukhulu kokubili ekuhlanganisweni kwelabhorethri kanye nokusetshenziswa kwezimboni. Ithimba laklama ngobuhlakani futhi lakha i-pincer ligand entsha, etholakala kalula futhi ezinzile ye-NN2 pincer ligand, okokuqala ngqa ethole ukukhethwa okusebenzayo nokuphezulu kwe-alkylamine derivatives kanye ne-terminal alkynes enezinhlobonhlobo zemithombo ye-nickel catalytic, eshibhile futhi elula ukuyithola. Ukusabela kokuxhumanisa kusetshenziswe ngempumelelo ekuguqulweni kwe-deamination kanye ne-alkynylation kwemikhiqizo yemvelo eyinkimbinkimbi kanye nama-molecule emithi, okugqamisa ukusebenza okuhle kokusabela kanye nokuhambisana kweqembu okusebenzayo, futhi kunikeza okusha ekuhlanganisweni kwe-alkynes ebalulekile ethathelwe indawo yi-alkyl. Nezindlela ezisebenzayo.
Isikhathi sokuthunyelwe: Novemba-22-2021