Ixabiso lePregabalin CAS 148553-50-8
Ingcaciso yeMveliso
Igama leMveliso: I-Pregabalin
INOMBOLO YE-CAS: 148553-50-8
Izithethantonye:
I-3-(AminoMethyl)-5-Methyl-hexanoic acid;
(3S)-3-(Aminomethyl)-5-methylhexanoic acid;
Iipropati zeKhemikhali kunye nezoBume:
Inkangeleko: Umgubo omhlophe ukuya komhlophe ongekho mhlophe
Uvavanyo: ≥99.0%
Ubuninzi: 0.997g/cm3
Iqondo lokunyibilika: 194-196℃
Indawo yokubilisa: 274℃ kwi-760 mmHg
Incopho yeFlash: 119.5℃
Isalathisi sokuqaqambisa: 1.464
Uxinzelelo lomphunga: 0.00153mmHg kwi-25°C
I-PSA: 63.32000
I-LogP: 1.78240
Ukunyibilika: Inyibilika kancinci emanzini.
Udidi: Amayeza; I-API; Iikhompawundi zePfizer; I-LYRICA;
Isicelo
I-S-Enantiomer yePregabalin. I-analogue ye-GABA esetyenziswa njenge-anticonvulsant. I-Anxiolytic analgesic esetyenziselwa ukunyanga iintlungu ze-neuropathic ezikwi-peripheral kunye ne-fibromyalgia.
I-Pregabalin luhlobo olutsha lweyeza elilwa nesifo sokuwa. Ulwakhiwo lwayo lwemolekyuli lunesakhiwo se-gamma aminobutyric acid, ngoko ke ineziphumo zokulwa noxinzelelo. Yaphuhliswa ngempumelelo yiPfizer ukunyanga i-peripheral neuralgia okanye unyango oluncedisayo lwe-partial seizures. NgoDisemba 2008, i-US Food and Drug Administration (FDA) yavuma i-pregabalin yokunyanga i-diabetes peripheral neuralgia (DPN) kunye ne-postherpetic neuralgia (PHN), ezona ntlungu zimbini zixhaphakileyo ze-neuropathic. Intlungu ye-neuropathic yenye yezona zinto zinzima ukunyanga iintlungu ezingapheliyo. Ibonakaliswa yintlungu engathandekiyo, ukutsha, kunye nokurhawuzelela. Zininzi izizathu ze-neuralgia. Isifo seswekile, usulelo (ezifana ne-shingles), umhlaza kunye ne-AIDS zonke zinokubangela imithambo-luvo. Iintlungu, malunga ne-3% yabantu eYurophu banesifo se-neuralgia.
Ukupakisha kunye nokugcina
Ukupakisha: 1kg/5kg/25kg okanye ngokusekelwe kwimfuno yomthengi.
Indawo yokugcina: Igcinwa kwisikhongozeli esipholileyo nesomileyo nesivalwe kakuhle. Gcina kude nokufuma kunye nokukhanya/ubushushu obunamandla.
Inkcazo
Nceda usithumelele i-imeyile ukuze ufumane i-COA.
