I-Alkynes ikhona ngokubanzi kwiimveliso zendalo, ii-molecule ze-biologically ezisebenzayo kunye nezinto ezisebenzayo eziphilayo. Kwangaxeshanye, zikwabalulekile phakathi kwi-organic synthesis kwaye zinokungena kwiinguqu ezininzi zeekhemikhali. Ke ngoko, ukuphuhliswa kweendlela ezilula nezisebenzayo zokwakha iialkynes zingxamisekile kwaye zifuneka. Nangona impendulo ye-Sonogashira eyenziwa yintsimbi yenguqu yenye yezona ndlela zisebenzayo kwaye zilungele ukudibanisa i-aryl okanye i-alkenyl substituted alkynes, ukusabela kokudibanisa okubandakanya i-alkyl electrophiles engasetyenziswanga ngenxa yeempendulo zecala ezifana nokupheliswa kwe-bH. Isagcwele imiceli mngeni kunye nophando oluncinci, ubukhulu becala bukhawulelwe kwii-alkanes ze-halogenated ezingenabubele kunye nexabiso eliphezulu. Ke ngoko, ukuphononongwa kunye nokuphuhliswa kwe-Sonogashira yokusabela kwezinto ezintsha, ezingabizi kwaye zifumaneka ngokulula kwi-alkylation reagents ziya kuba zibaluleke kakhulu zombini kwi-laboratory synthesis kunye nezicelo zoshishino. Iqela lenze ngobuchule kwaye liphuhlise i-amide-type NN2 pincer ligand entsha, efumaneka ngokulula kwaye izinzile, okokuqala ngqa yaqonda ukhetho olufanelekileyo kunye noluphezulu lwe-alkylamine derivatives kunye ne-alkynes ye-terminal kunye noluhlu olubanzi lwemithombo ye-nickel catalytic, ephantsi kwaye kulula ukuyifumana. I-reaction cross-coupling reaction isetyenziswe ngempumelelo kwi-deamination kade kunye nokuguqulwa kwe-alkynylation yeemveliso zendalo ezintsonkothileyo kunye neemolekyuli zamachiza, ezibonisa ukusebenza kakuhle kokusabela kunye nokuhambelana kweqela elisebenzayo, kwaye ibonelela ngobutsha bokuhlanganiswa kwee-alkyne ezibalulekileyo ezifakwe endaweni ye-alkyl. Kunye neendlela ezisebenzayo.
Ixesha lokuposa: Nov-22-2021