Ii-Alkynes zifumaneka kakhulu kwiimveliso zendalo, kwiimolekyuli ezisebenzayo ngokwebhayoloji kunye nezinto ezisebenzayo ze-organic. Kwangaxeshanye, zikwabalulekile kwi-organic synthesis kwaye zinokudlula kwiimpendulo ezininzi zokuguqulwa kweekhemikhali. Ke ngoko, uphuhliso lweendlela zokwakha ii-alkynes ezilula nezisebenzayo lungxamisekile kwaye luyimfuneko kakhulu. Nangona i-Sonogashira reaction ekhuthazwa zii-transition metals yenye yezona ndlela zisebenzayo nezilula zokwenza i-aryl okanye i-alkenyl substituted alkynes, i-coupling reaction equka ii-alkyl electrophiles ezingasebenziyo ibangelwa ziimpendulo ezingezizo ezinje ngokususwa kwe-bH. Isenemingeni kwaye uphando oluncinci, ikakhulu lukhawulelwe kwi-alkanes ezingezizo ezokusingqongileyo nezibizayo ze-halogenated. Ke ngoko, uphando kunye nophuhliso lwe-Sonogashira reaction yee-reagents ezintsha ze-alkylation, ezingabizi kakhulu nezifumaneka lula ziya kuba nentsingiselo enkulu kokubini kwi-laboratory synthesis kunye nezicelo zemizi-mveliso. Iqela liyile ngobuchule kwaye laphuhlisa i-pincer ligand entsha, efumaneka lula kwaye izinzile ye-NN2 pincer ligand, eyathi okokuqala yafumanisa ukhetho olusebenzayo noluphezulu lwee-alkylamine derivatives kunye ne-terminal alkynes ezinoluhlu olubanzi lwemithombo ye-nickel catalytic, engabizi kwaye kulula ukuyifumana. I-cross-coupling reaction isetyenziswe ngempumelelo ekuguqulweni kwe-deamination kunye ne-alkynylation kade kweemveliso zendalo ezintsonkothileyo kunye neemolekyuli zamayeza, nto leyo egxininisa ukusebenza kakuhle kwempendulo kunye nokuhambelana kweqela okusebenzayo, kwaye ibonelela ngobutsha bokwenziwa kwee-alkynes ezibalulekileyo ezithathelwe indawo yi-alkyl. Neendlela ezisebenzayo.
Ixesha lokuthumela: Novemba-22-2021