Li-alkyne li fumaneha haholo lihlahisoa tsa tlhaho, limolek'hule tse sebetsang ka baeloji le thepa e sebetsang ea tlhaho. Ka nako e ts'oanang, hape ke li-intermediate tsa bohlokoa tlhahisong ea lintho tse phelang 'me li ka feta liketsong tse ngata tsa phetoho ea lik'hemik'hale. Ka hona, nts'etsopele ea mekhoa e bonolo le e sebetsang ea kaho ea li-alkyne e potlakile haholo ebile ea hlokahala. Le hoja karabelo ea Sonogashira e susumetsoang ke litšepe tsa phetoho e le e 'ngoe ea litsela tse sebetsang ka ho fetisisa le tse bonolo tsa ho kopanya li-alkyne tse nkeloang sebaka ke aryl kapa alkenyl, karabelo ea ho kopanya e kenyeletsang li-electrophile tsa alkyl tse sa sebetseng e bakoa ke liketso tse mpe tse kang ho felisoa ha bH. E ntse e tletse liphephetso le lipatlisiso tse fokolang, haholo-holo tse lekanyelitsoeng ho li-alkanes tse se nang botsoalle tikolohong le tse turang tsa halogenated. Ka hona, ho batlisisa le nts'etsopele ea karabelo ea Sonogashira ea li-reagent tse ncha tsa alkylation tse theko e tlaase le tse fumanehang habonolo e tla ba ea bohlokoa haholo tlhahisong ea laboratori le lits'ebetsong tsa indasteri. Sehlopha se hlophisitse le ho ntshetsa pele ka bohlale pincer ligand e ncha, e fumanehang habonolo le e tsitsitseng ya mofuta wa amide NN2, e ileng ya etsa hore ka lekgetlo la pele e fumane kgetho e sebetsang le e phahameng ya di-alkylamine derivatives le di-alkynes tsa terminal tse nang le mefuta e mengata ya mehlodi ya nickel catalytic, e theko e tlase ebile e le bonolo ho e fumana. Karabelo ya ho kopanya e sebedisitsweng ka katleho phetohong ya morao ya deamination le alkynylation ya dihlahiswa tse rarahaneng tsa tlhaho le dimolek'hule tsa dithethefatsi, e leng se totobatsang tshebetso e ntle ya karabelo le ho tsamaellana ha sehlopha ka tshebetso, mme e fana ka botjha bakeng sa ho kopanya di-alkynes tsa bohlokwa tse nketsweng sebaka ke alkyl. Le mekgwa e sebetsang.
Nako ea poso: Pulungoana-22-2021