Isku xidhka Sonogashira ee baabi'iya nikkel-ka ee cusbada alkylpyridinium oo ay suurtagelisay NN2 pincer ligand

Alkynes waxay si weyn ugu jiraan wax soo saarka dabiiciga ah, molecules-ka firfircoon ee bayoloji ahaan iyo agabka shaqada dabiiciga ah. Isla mar ahaantaana, waxay sidoo kale yihiin dhexdhexaad muhiim ah oo ku jira isku-darka dabiiciga ah waxayna mari karaan falcelinno isbeddel kiimiko oo badan. Sidaa darteed, horumarinta hababka dhismaha alkynes ee fudud oo hufan ayaa si gaar ah degdeg ah oo loo baahan yahay. Inkasta oo falcelinta Sonogashira ee ay kiciso biraha kala-guurka ay tahay mid ka mid ah siyaabaha ugu waxtarka badan uguna habboon ee lagu sameeyo alkynes-ka beddelka aryl ama alkenyl, falcelinta isku-xidhka ee ku lug leh electrophiles-ka alkyl ee aan firfircoonayn waxaa sabab u ah falcelinta dhinaca sida ka saarista bH. Wali waxaa ka buuxa caqabado iyo cilmi-baaris yar, oo inta badan ku kooban alkanes-ka halogenated ee aan deegaanka u wanaagsanayn oo qaali ah. Sidaa darteed, sahaminta iyo horumarinta falcelinta Sonogashira ee reagents-ka alkylation-ka cusub, jaban oo si fudud loo heli karo waxay noqon doontaa mid muhiimad weyn u leh labadaba isku-darka shaybaarka iyo codsiyada warshadaha. Kooxdu si xariif ah ayay u qaabeeyeen una sameeyeen ligand cusub, oo si fudud loo heli karo oo deggan oo amide-nooca NN2 pincer ligand ah, kaas oo markii ugu horreysay ogaaday xulashada hufan iyo sare ee wax soo saarka alkylamine iyo alkynes terminal oo leh noocyo badan oo ilo catalytic nickel ah, raqiis ah oo si fudud loo heli karo. Falcelinta isku-xidhka isku-dhafka ah ayaa si guul leh loogu dabaqay isbeddelka dambe ee kala-goynta iyo wax-ka-beddelka alkynylation ee alaabada dabiiciga ah ee adag iyo molecules-ka daroogada, taas oo iftiiminaysa waxqabadka wanaagsan ee falcelinta iyo is-waafajinta kooxda shaqaynaysa, waxayna bixisaa cusub oo loogu talagalay isku-darka alkynes-ka muhiimka ah ee alkyl-badala. Iyo habab wax ku ool ah.