Iwe unoshanda mumunda we biomedical research? Kana zvakadaro, saka unogona kunge wakanzwa nezveSulfo-NHS. Sezvo basa rakakosha remukomboni uyu mukutsvaga richiramba richizivikanwa, komisheni iyi iri kupinda mumarabhoritari akawanda pasi rose. Muchinyorwa chino, tinokurukura kuti Sulfo-NHS chii uye nei chiri chishandiso chakakosha kune avo vanodzidza biological sainzi.
Kutanga, chii chinonzi Sulfo-NHS? Zita racho rinenge rakareba, saka ngatiriparadzei. Sulfo inomirira sulfonic acid uye NHS inomirira N-hydroxysuccinimide. Kana aya macompound maviri asangana,Sulfo-NHSinogadzirwa. Mushonga uyu une mashandisiro akati wandei mukutsvagisa biomedical, asi chimwe chezvakakosha zvivakwa kugona kusarudza mapuroteni.
Sulfo-NHS inoshanda nekuita nema primary amines (kureva -NH2 mapoka) pamacheni eparutivi ezvisaririra zvelysine mumapuroteni. Chaizvoizvo, Sulfo-NHS inosanganisa "tag" mapuroteni, zvichiita kuti zvive nyore kuziva uye kuongorora mumhando dzakasiyana dzekuyedza. Izvi zvakakonzera kuti nzvimbo dzakawanda dzekutsvaga dzikwanise kufambira mberi nekururama kukuru uye nepamusoro-soro yehuwandu.
Saka, chii chinonzi Sulfo-NHS chinoshandiswa? Kumwe kushandiswa kwakajairwa kwekomputa iyi kuri mukutsvaga kweimmunology. Sulfo-NHS yakaratidzwa kunyatso nyora masoja ekudzivirira chirwere uye maantigen, achivhura nzira nyowani dzekudzidza nezve immune system kusagadzikana uye zvirwere. Uyezve,Sulfo-NHSinogona kushandiswa muzvidzidzo zveprotein-protein interaction sezvo ichibvumira vatsvakurudzi kuti vaone nekukurumidza uye nyore nyore apo mapuroteni maviri akabatana.
Imwe nzvimbo iyo Sulfo-NHS inoshandiswa zvakanyanya ndeye yeproteomics. Proteomics inodzidza chimiro uye kushanda kwese mapuroteni mumunhu, uyeSulfo-NHSchinhu chakakosha pakuongorora uku. Nekuisa mapuroteni neSulfo-NHS, vaongorori vanogona kuita ongororo kuti vawane ruzivo rwakadzama nezveproteome yechipenyu yakapihwa, iyo inogona kubatsira kuona zvingangoita biomarker yechirwere.
Sulfo-NHS inoitawo basa mukugadzirwa kwemishonga mitsva. Kana vaongorori vari kuyedza kugadzira mushonga mutsva, zvakakosha kuve nechokwadi kuti unonangana neprotein inodiwa uye kwete chero imwe puroteni iri mumuviri. NokushandisaSulfo-NHSkusarudza mapuroteni, vatsvakurudzi vanogona kuona zvinangwa zvemishonga inogona kubatsira kukurumidza kugadzirwa kwezvinodhaka.
Saka hezvo unayo! Sulfo-NHS inogona kunge isiri izwi rinonyatsozivikanwa kunze kwenharaunda yesainzi, asi komisheni iyi iri kukurumidza kuita chishandiso chakakosha mukutsvaga kwebiomedical. Kubva pakutsvagisa immunology kuenda kuproteomics kusvika pakuvandudza zvinodhaka, Sulfo-NHS iri kubatsira vaongorori kuita budiriro huru munzvimbo idzi uye isu tinofara kuona kuti ndezvipi zvakawanikwa zvinotevera.
Nguva yekutumira: Jun-12-2023