Alkynes inowanikwa zvakanyanya mune zvakasikwa zvigadzirwa, biologically inoshanda mamorekuru uye organic inoshanda zvinhu. Panguva imwecheteyo, iwo akakosha epakati mune organic synthesis uye anogona kusangana neakawanda makemikari shanduko maitiro. Nokudaro, kugadzirwa kwemaitiro akareruka uye anoshanda ekuvaka alkynes inonyanya kukurumidza uye inodiwa. Kunyange zvazvo maitiro eSonogashira akakonzerwa nekuchinja kwesimbi ndeimwe yenzira dzakanakisisa uye dzakasununguka dzekugadzira aryl kana alkenyl inotsiva alkynes, maitiro ekubatanidza anosanganisira asina-activated alkyl electrophiles anokonzerwa nekuita kweparutivi sekubvisa bH. Zvichiri kuzere nematambudziko uye kushoma kutsvagisa, kunyanya kuganhurirwa kune nharaunda isina hushamwari uye inodhura halogenated alkanes. Nokudaro, kuongorora nekuvandudzwa kweSonogashira maitiro ezvitsva, zvisingadhuri uye zviri nyore kuwanikwa alkylation reagents zvichave zvakakosha zvikuru mu laboratory synthesis uye kushandiswa kwemaindasitiri. Chikwata chakagadzira zvine hungwaru uye chakagadzira chitsva, chiri nyore kuwanikwa uye chakagadzikana amide-mhando NN2 pincer ligand, iyo kekutanga yakaziva inoshanda uye yakakwirira kusarudzwa kwealkylamine derivatives uye materminal alkynes ane huwandu hwakawanda hwenickel catalytic sources, yakachipa uye iri nyore kuwana. Iko kupindirana kwekubatanidza maitiro kwakave kwakabudirira kushandiswa kune yekupedzisira deamination uye alkynylation shanduko yezvakaoma zvigadzirwa zvechisikigo uye mamorekuru ezvinodhaka, izvo zvinoratidzira kuita kwakanaka kwekuita uye kushanda kweboka kuenderana, uye inopa hutsva hwekubatanidzwa kweakakosha alkyl-inotsiva alkynes. Uye nzira dzinoshanda.
Nguva yekutumira: Nov-22-2021