Guhuza Sonogashira y'umunyu wa alkylpyridinium hakoreshejwe nikeli bikozwe muri ligand ya pincer ya NN2

Alkynes ziboneka cyane mu bicuruzwa karemano, mu binyabutabire bikora ku binyabuzima ndetse no mu bikoresho bikora ku binyabuzima. Muri icyo gihe, ni ingenzi mu guhuza imikorere ya organic kandi zishobora guhinduka cyane mu buryo bw’imiti. Kubwibyo, iterambere ry’uburyo bworoshye kandi bunoze bwo kubaka alkynes ni ngombwa cyane kandi rikenewe. Nubwo uburyo bwa Sonogashira buterwa n’ibyuma bihindura imiterere y’ibintu ari bumwe mu buryo bwiza kandi bworoshye bwo gukora alkynes za aryl cyangwa alkenyl, uburyo bwo guhuza imiterere y’ibintu bya alkyl electrophiles bidakora buterwa n’ingaruka mbi nko gukuraho bH. Haracyari imbogamizi nyinshi kandi ubushakashatsi buke, ahanini bugarukira kuri alkanes za halogenated zitabungabunga ibidukikije kandi zihenze. Kubwibyo, ubushakashatsi n’iterambere ry’uburyo bwa Sonogashira bwo gukora alkylation nshya, zihendutse kandi zoroshye kuboneka bizaba ingirakamaro cyane haba mu gukora laboratwari no mu nganda. Itsinda ryakoze kandi rikora neza icyuma gishya cya NN2 pincer ligand, cyoroshye kuboneka kandi gihamye, cyabonye bwa mbere uburyo bwiza kandi bworoshye bwo guhitamo alkylamine derivatives na terminal alkynes hamwe n’ubwoko bwinshi bw’ibintu bitera imbaraga bya nickel, bihendutse kandi byoroshye kubibona. Uburyo bwo guhuza ibintu bwakoreshejwe neza mu guhindura ibintu bikomoka ku bimera n’ibikomoka ku bimera mu buryo butinze, bigaragaza imikorere myiza y’uburyo ibintu bihinduka n’imikorere y’amatsinda, kandi bigatanga uburyo bushya bwo gukora alkynes z’ingenzi zasimbuwe na alkyl. N’uburyo bufatika.