Povidone Iodine CAS 25655-41-8
Povidone iodine is a complex of povidone K30 with iodine, which has a strong killing effect on bacteria, viruses, fungi, molds and spores. Stable, non-irritating, completely water soluble.
Product Attributes
Pharmacopoeia Name: Povidone Iodine, Povidone-Iodine (USP), Povidone-Iodinated (EP)
Chemical Name: Complex of polyvinylpyrrolidone with iodine
Product name :Povidone Iodine
Cas No .: 25655-41-8; 74500-22-4
Molecular Weight : 364.9507
Molecular Formula : C6H9I2NO
Mechanism of action : PVP is a hydrophilic polymer that has no antibacterial effect. However, due to its affinity for cell membranes, it can directly lead iodine to the cell surface of bacteria, which offers great significance for improving the antibacterial activity of iodine. The target of iodine is the bacterial cytoplasm and cytoplasmic membrane, which kills bacteria immediately in a matter of seconds. When the molecules necessary for the survival of organisms such as sulfhydryl compounds, peptides, proteins, lipids and cytosine are contacted with PVP-I, they are immediately oxidized or iodinated by iodine to lose their activity and achieve a long-term bactericidal action.
Povidone iodine is a complex of iodine with povidone. It occurs as a yellowish brown to reddish brown amorphous powder, having a slight characteristic odour. Its solution is acid to litmus. Soluble in water and in alcohol, practically insoluble in chloroform, in carbon tetrachloride, in ether, in solvent hexane, and in acetone. It is an external antiseptic with a broad microbicidal spectrum against bacteria, fungi, viruses, protozoa, and yeasts. This gel has about 1.0% available iodine.
Quality Standard
|
Pharmacopoeia standard
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Appearance
|
Effective iodine /%
|
Residue on ignition/%
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Loss on drying /%
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Iodine ion /%
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Arsenic salt/ppm
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Heavy metal / ppm
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Nitrogen content /%
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PH value (10% aqueous solution)
|
|
CP2010
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Reddish brown to yellow brown amorphous powder
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9.0-12.0
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≤0.1
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≤8.0
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≤6.6
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≤1.5
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≤20
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9.5-11.5
|
/
|
|
USP32
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≤0.025
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≤8.0
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≤6.6
|
/
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≤20
|
9.5-11.5
|
/
|
||
|
EP7.0
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≤0.1
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≤8.0
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≤6.0
|
/
|
/
|
/
|
1.5-5.0
|
Effective iodine 20% (enterprise standard)
|
Appearance
|
Effective iodine /%
|
Residue on ignition/%
|
Loss on drying /%
|
Iodine ion /%
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Arsenic salt/ppm
|
Heavy metal / ppm
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Nitrogen content /%
|
|
Reddish brown to yellow brown amorphous powder
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18.5-21.0
|
≤0.1
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≤8.0
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≤13.5
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≤1.5
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≤20
|
8.0-11.0
|
The major indications of Povidone iodine are as follows:
1. it can be used for treating suppurative dermatitis, fungal skin infection, and small area of mild burns; can also be used for disinfection of small area of skin and mucous membrane wound.
2. It can be used for the prevention and tropic disinfection of various kinds of diseases such as bacterial and mould vaginitis, cervical erosion, trichomonas vaginitis, genital itching, smelly genital infection, yellow and smelly leucorrhea, comprehensive genital inflammation, elderly vaginitis, herpes, gonorrhea, syphilis and genital warts.
3. It can be used for treating glans inflammation, posthitis, and the disinfection of genitalia and the surrounding area. Also used for the prevention and tropical treatment and disinfection of gonorrhea, syphilis, and genital warts.
4. it can be applied to the disinfection of cutlery and tableware.
5. it can be used or the disinfection surgical area of skin.
25KG/cardboard drum, , sealed, kept in a cool dry and dark place.
