Kuphatikizika kwa nickel-catalyzed deaminative Sonogashira kwa mchere wa alkylpyridinium wothandizidwa ndi NN2 pincer ligand

Alkynes amapezeka kwambiri muzinthu zachilengedwe, mamolekyu omwe amagwira ntchito ndi biologically ndi zida zogwirira ntchito. Panthawi imodzimodziyo, iwonso ndi ofunikira pakati pa organic synthesis ndipo amatha kukumana ndi kusintha kwakukulu kwa mankhwala. Choncho, kupanga njira zosavuta komanso zogwira mtima za alkynes ndizofunika kwambiri komanso zofunikira. Ngakhale kuti Sonogashira anachita catalyzed ndi kusintha zitsulo ndi imodzi mwa njira zothandiza kwambiri ndi yabwino lithe aryl kapena alkenyl m'malo alkynes, kugwirizana anachita okhudza sanali adamulowetsa alkyl electrophiles ndi chifukwa mbali zochita monga bH kuchotsa. Odzalabe ndi zovuta komanso kafukufuku wocheperako, makamaka ma alkanes osakonda zachilengedwe komanso okwera mtengo. Choncho, kufufuza ndi chitukuko cha Sonogashira anachita zatsopano, zotsika mtengo komanso zopezeka mosavuta alkylation reagents adzakhala ofunika kwambiri mu kaphatikizidwe zasayansi ndi mafakitale ntchito. Gululo linapanga mwanzeru ndikupanga njira yatsopano, yopezeka mosavuta komanso yokhazikika ya amide-mtundu wa NN2 pincer ligand, yomwe kwa nthawi yoyamba inazindikira kusankha koyenera komanso kwakukulu kwa zotumphukira za alkylamine ndi ma terminal alkynes okhala ndi magwero osiyanasiyana othandizira nickel, otsika mtengo komanso osavuta kupeza. Kuphatikizika kwa mtanda kwagwiritsidwa ntchito bwino pa deamination mochedwa ndi alkynylation kusinthidwa kwa zinthu zovuta zachilengedwe ndi mamolekyu a mankhwala, zomwe zimawunikira momwe zimakhalira bwino komanso magwiridwe antchito amagulu, ndipo zimapereka zachilendo pakuphatikizika kwa ma alkynes ofunikira olowa m'malo. Ndi njira zothandiza.