Mtengo wa Medroxyprogesterone Acetate CAS 71-58-9

Medroxyprogesterone Acetate, yomwe imadziwikanso kuti Medroxyprogesterone 17-acetate kapena MPA, ndi progestogen yopangidwa ndi mankhwala komanso steroidal progestin. Imachokera ku progesterone ya mahomoni a anthu. Imaletsa umuna ndipo imawonjezera kuchuluka kwa mayendedwe a mazira kuchokera m'machubu a fallopian kupita ku chiberekero mwa akazi akapatsidwa ovulation isanayambe. Medroxyprogesterone 17-acetate imaletsa ovulation mwa makoswe akabayidwa tsiku lomaliza la diestrus. Imakhalanso ndi anti-androgenic effect mwa makoswe, imachepetsa kuchuluka kwa testosterone m'magazi kudzera mu kuyambitsa ntchito ya hepatic testosterone reductase. Medroxyprogesterone 17-acetate imawonetsa mphamvu zoletsa chitetezo chamthupi mu vitro ndi mu vivo, ikuletsa kupanga IFN-γ ndi maselo a CD2/CD3/CD28-stimulated peripheral blood mononuclear (PBMCs) pamlingo wa ≥10 nM ndikuwonjezera kupulumuka kwa allografts ya khungu la kalulu. Mankhwala obayidwa jakisoni okhala ndi medroxyprogesterone 17-acetate agwiritsidwa ntchito ngati njira zolerera.