He nui ngā alkyne kei roto i ngā hua taiao, i ngā ngota koiora kaha me ngā rauemi mahi waro. I taua wā anō, he takawaenga nui hoki rātou i roto i te hanganga waro, ā, ka taea te whai i ngā tauhohenga whakawhiti matū maha. Nō reira, he mea tino tere te whakawhanake i ngā tikanga hanga alkyne māmā me te whai hua, me te hiahia hoki. Ahakoa ko te tauhohenga Sonogashira i whakakorikoria e ngā konganuku whakawhiti tētahi o ngā huarahi tino whai hua me te watea ki te hanga aryl, alkenyl rānei ngā alkyne whakakapinga, ko te tauhohenga hononga e uru ana ki ngā electrophile alkyl kāore i whakahohehia nā ngā tauhohenga taha pēnei i te whakakorenga bH. He maha tonu ngā wero me te iti o te rangahau, ko te nuinga he iti noa iho ki ngā alkane halogenated kino ki te taiao me te utu nui. Nō reira, ko te tūhuratanga me te whakawhanaketanga o te tauhohenga Sonogashira o ngā tauhohenga alkylation hou, iti te utu me te ngāwari ki te tiki ka nui te hiranga i roto i te hanganga taiwhanga me ngā tono ahumahi. I hoahoa mohio te tīma me te whakawhanake i tētahi ligand pincer momo amide NN2 hou, ngāwari ki te tiki me te pumau, i kite tuatahi i te kōwhiringa whai hua me te teitei o ngā alkylamine derivatives me ngā alkyne whakamutunga me te whānuitanga o ngā puna whakakorikori nickel, iti te utu me te ngāwari ki te tiki. Kua angitu te whakamahi i te tauhohenga honohono-whakawhiti ki te whakarerekētanga deamination me te alkynylation o ngā hua taiao matatini me ngā ngota rongoā, e whakaatu ana i te pai o te mahi tauhohenga me te hototahi rōpū mahi, ā, e whakarato ana i te mea hou mō te hanganga o ngā alkynes whakakapi-alkyl nui. Me ngā tikanga mahi.
Wā tuku: Whiringa-ā-rangi 22-2021