Alkynes muaj ntau nyob rau hauv cov khoom ntuj, cov tshuaj lom neeg ua haujlwm thiab cov khoom siv ua haujlwm organic. Tib lub sijhawm, lawv kuj yog cov khoom siv tseem ceeb hauv kev tsim cov organic thiab tuaj yeem dhau los ntawm ntau yam kev hloov pauv tshuaj lom neeg. Yog li ntawd, kev tsim cov txheej txheem yooj yim thiab ua haujlwm tau zoo alkynes yog qhov tseem ceeb thiab xav tau. Txawm hais tias Sonogashira cov tshuaj tiv thaiv catalyzed los ntawm kev hloov pauv hlau yog ib qho ntawm cov txheej txheem zoo tshaj plaws thiab yooj yim tshaj plaws los tsim cov aryl lossis alkenyl hloov alkynes, qhov kev sib txuas ua ke uas muaj cov alkyl electrophiles tsis ua haujlwm yog vim muaj cov tshuaj tiv thaiv sab xws li bH tshem tawm. Tseem muaj kev cov nyom thiab kev tshawb fawb tsawg dua, feem ntau txwv rau cov alkanes halogenated tsis zoo rau ib puag ncig thiab kim. Yog li ntawd, kev tshawb nrhiav thiab kev txhim kho ntawm Sonogashira cov tshuaj tiv thaiv ntawm cov tshuaj alkylation tshiab, pheej yig thiab yooj yim nrhiav tau yuav muaj txiaj ntsig zoo hauv kev tsim cov chaw kuaj mob thiab kev siv hauv kev lag luam. Cov pab pawg neeg tau tsim thiab tsim cov ligand amide-type NN2 pincer tshiab, yooj yim nrhiav tau thiab ruaj khov, uas thawj zaug tau paub txog kev xaiv cov alkylamine derivatives thiab terminal alkynes nrog ntau yam nickel catalytic qhov chaw, pheej yig thiab yooj yim tau txais. Cov tshuaj tiv thaiv cross-coupling tau ua tiav rau kev hloov pauv lig thiab alkynylation ntawm cov khoom ntuj tsim thiab cov tshuaj molecules, uas qhia txog kev ua tau zoo ntawm cov tshuaj tiv thaiv thiab kev sib raug zoo ntawm pawg, thiab muab cov khoom tshiab rau kev tsim cov alkyl-substituted alkynes tseem ceeb. Thiab cov txheej txheem ua tau zoo.
Lub sijhawm tshaj tawm: Kaum Ib Hlis-22-2021