ʻO ka hui ʻana o Sonogashira deaminative i hoʻopili ʻia e Nickel-catalyzed o nā paʻakai alkylpyridinium i hiki ke hoʻāla ʻia e ka ligand pincer NN2

Loaʻa nui nā Alkynes i nā huahana kūlohelohe, nā molekala biologically active a me nā mea hana organik. I ka manawa like, he mau mea waena koʻikoʻi lākou i ka synthesis organik a hiki ke hana i nā hopena hoʻololi kemika he nui. No laila, ʻo ka hoʻomohala ʻana i nā ʻano hana kūkulu alkynes maʻalahi a maikaʻi hoʻi he mea wikiwiki loa a pono. ʻOiai ʻo ka hopena Sonogashira i hoʻoulu ʻia e nā metala hoʻololi kekahi o nā ala kūpono a maʻalahi hoʻi e synthesize i nā aryl a i ʻole alkenyl substituted alkynes, ʻo ka hopena hui e pili ana i nā alkyl electrophiles i hoʻāla ʻole ʻia ma muli o nā hopena ʻaoʻao e like me ka hoʻopau ʻana o bH. Piha mau i nā pilikia a me ka noiʻi liʻiliʻi, ʻo ka mea nui i kaupalena ʻia i nā alkanes halogenated aloha ʻole i ke kaiapuni a pipiʻi. No laila, ʻo ka ʻimi ʻana a me ka hoʻomohala ʻana i ka hopena Sonogashira o nā reagents alkylation hou, ʻaʻole pipiʻi a maʻalahi hoʻi e loaʻa he mea nui loa ia ma ka synthesis laboratory a me nā noi ʻoihana. Ua hoʻolālā akamai ka hui a hoʻomohala i kahi ligand pincer amide-type NN2 hou, maʻalahi a paʻa, ka mea no ka manawa mua i ʻike i ke koho kūpono a kiʻekiʻe o nā derivatives alkylamine a me nā alkynes terminal me kahi ākea o nā kumu catalytic nickel, makepono a maʻalahi hoʻi e loaʻa. Ua hoʻopili pono ʻia ka hopena cross-coupling i ka deamination hope a me ka hoʻololi ʻana o ka alkynylation o nā huahana kūlohelohe paʻakikī a me nā molekala lāʻau lapaʻau, kahi e hōʻike ana i ka hana maikaʻi o ka hopena a me ka hoʻohālikelike ʻana o ka hui hana, a hāʻawi i ka mea hou no ka synthesis o nā alkynes i hoʻololi ʻia e ka alkyl. A me nā ʻano hana kūpono.