Nickel-catalyzed deaminative Sonogashira ka hui ʻana o nā paʻakai alkylpyridinium i hoʻohana ʻia e NN2 pincer ligand

Loaʻa nui ʻia nā Alkynes i nā huahana kūlohelohe, nā molekole olaola a me nā mea hana kūlohelohe. I ka manawa like, he mau mea koʻikoʻi nō hoʻi lākou i ka synthesis organik a hiki ke hana i nā hopena hoʻololi kemika nui. No laila, ʻo ka hoʻomohala ʻana i nā ʻano hana hana alkynes maʻalahi a pono hoʻi. ʻOiai ʻo ka hopena Sonogashira i hoʻopaʻa ʻia e nā metala hoʻololi ʻo ia kekahi o nā ala kūpono a maʻalahi hoʻi e synthesize i ka aryl a i ʻole alkenyl substituted alkynes, ʻo ka hoʻohui ʻana e pili ana i nā electrophiles alkyl i hoʻāla ʻole ʻia ma muli o nā hopena ʻaoʻao e like me ka hoʻopau ʻana i ka bH. Ua piha i nā pilikia a me ka liʻiliʻi o ka noiʻi ʻana, i kaupalena ʻia i nā alkanes halogenated pili ʻole i ke kaiapuni. No laila, ʻo ka ʻimi ʻana a me ka hoʻomohala ʻana o ka hopena Sonogashira o nā mea hou alkylation hou, maʻalahi a maʻalahi hoʻi e loaʻa i ke koʻikoʻi nui ma ka synthesis laboratory a me nā noi ʻoihana. Ua hoʻolālā akamai a hoʻomohala ka hui i kahi ligand amide-type NN2 pincer ligand hou, maʻalahi a paʻa, a no ka manawa mua i ʻike i ka maikaʻi a me ke koho kiʻekiʻe o nā alkylamine derivatives a me nā alkynes terminal me kahi ākea o nā kumu nickel catalytic, maʻalahi a maʻalahi ke loaʻa. Ua hoʻohana maikaʻi ʻia ka hopena hoʻohui i ka deamination hope a me ka hoʻololi ʻana o ka alkynylation o nā huahana kūlohelohe paʻakikī a me nā molekala lāʻau, e hōʻike ana i ka hoʻokō maikaʻi ʻana a me ka hui pū ʻana o ka hana, a hāʻawi i nā mea hou no ka synthesis o nā alkyl-substituted alkynes koʻikoʻi. A me nā ʻano hana.