Haɗin gishirin alkylpyridinium mai narkewa wanda aka haɗa da sinadarin nickel wanda aka kunna ta hanyar NN2 pincer ligand

Alkynes suna nan a cikin samfuran halitta, ƙwayoyin halitta masu aiki da kayan aiki na halitta. A lokaci guda, suna da mahimmanci a cikin haɗakar kwayoyin halitta kuma suna iya fuskantar yawan halayen canza sinadarai. Saboda haka, haɓaka hanyoyin gina alkynes masu sauƙi da inganci yana da matuƙar gaggawa kuma ana buƙata. Kodayake amsawar Sonogashira da ƙarfe masu canzawa ke haifarwa yana ɗaya daga cikin hanyoyin da suka fi tasiri da dacewa don haɗa alkynes da aka maye gurbin aryl ko alkenyl, haɗin kai da ya haɗa da electrophiles na alkyl waɗanda ba a kunna su ba yana faruwa ne saboda halayen gefe kamar kawar da bH. Har yanzu cike yake da ƙalubale da ƙarancin bincike, galibi an iyakance shi ga alkanes masu rashin kyau da tsada na halogenated. Saboda haka, bincike da haɓaka amsawar Sonogashira na sabbin reagents na alkylation, masu araha da sauƙin samu zai kasance da matuƙar mahimmanci a cikin haɗakar dakin gwaje-gwaje da aikace-aikacen masana'antu. Tawagar ta tsara kuma ta ƙirƙiro sabuwar ligand mai sauƙin samu kuma mai karko ta NN2 pincer ligand, wacce a karon farko ta gano ingantaccen zaɓi na abubuwan da aka samo daga alkylamine da kuma terminal alkynes tare da nau'ikan tushen nickel catalytic iri-iri, mai araha kuma mai sauƙin samu. An yi amfani da wannan haɗin gwiwa cikin nasara wajen gyara ƙarshen deamination da alkynylation na samfuran halitta masu rikitarwa da ƙwayoyin magunguna, wanda ke nuna kyakkyawan aikin amsawa da kuma dacewa da ƙungiyoyin aiki, kuma yana samar da sabon abu don haɗa muhimman alkynes masu maye gurbin alkyl. Da kuma hanyoyin aiki.